Description:HRP conjugated goat polyclonal antibody to human C reactive protein (CRP)

Purification:Protein G affinity purified

Product Type:Tracer antibody in matched antibody pair, HRP conjugated

Target Protein:Human CRP

Immunogen:Purified CRP from human pleural fluid

Specificity:No detectable cross-reaction with human normal serum proteins.

Species Reacitvity: Human, others not tested

Host: Goat

Storage Buffer Formulation:Mixture of 50% glycerol and 50% PH7.2 0.01M PBS. Final PH = 7.0 ± 0.1.

Storage: Store at -20^oC

Research Area:Inflammatory and cardiovascular diseases

Background:

C –reactive protein (CRP) is an acute phase protein that is comprised of five identical 23kDa subunits. The protein increases rapidly in response to inflammation, trauma and infection, and drops to normal level when the conditions no longer present. CRP plays a role in innate immunity by binding to phosphachlolin on the surface of damaged cells or certain microbes, and activating the C1q complex in complement system. CRP is primarily produced by hepatocytes under the stimulation by inflammatory cytokines including IL-6 and TNF-alpha. Elevated CRP level is implicated with bacterial infection, autoimmune diseases, trauma and post-surgical complications. Study has shown that people with higher CRP baseline have a higher disposition to develop cardiovascular diseases such as heart attack and stroke.

Application:

ELISA:In combination with CRP capture antibody [Clone 63F4, Cat No: MO-M40023A], this HRP conjugated antibody can be used as tracer in Sandwich ELISA for CRP detection.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.